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Updated: Feb 8, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
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LSD1除去は抗腫瘍免疫を刺激し,チェックポイントブロックを可能にします

Wanqiang Sheng1, Martin W LaFleur2, Thao H Nguyen3

  • 1Division of Newborn Medicine and Epigenetics Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|June 26, 2018
PubMed
まとめ

癌細胞におけるLSD1の抑制は,反復的要素の発現を増加させ,インターフェロンを活性化することによって,抗腫瘍免疫を高めます. このアプローチは免疫療法の反応を高め,新しいがん治療戦略を示唆しています.

キーワード:
LSD1 についてMHC-1 についてPD-1/PD-L1についてRISC についてT細胞の浸透抗腫瘍免疫dsRNA について内生レトロウイルス要素免疫チェックポイントの封鎖インターフェロン

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