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関連する概念動画

Non-nuclear Inheritance01:29

Non-nuclear Inheritance

23.3K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
23.3K
Nuclear Fusion02:45

Nuclear Fusion

33.9K
The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
33.9K
Nuclear Stability03:18

Nuclear Stability

23.3K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.3K
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

8.8K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
8.8K
Nuclear Transmutation03:20

Nuclear Transmutation

20.7K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
20.7K
Nuclear Fission02:50

Nuclear Fission

12.5K
Many heavier elements with smaller binding energies per nucleon can decompose into more stable elements that have intermediate mass numbers and larger binding energies per nucleon—that is, mass numbers and binding energies per nucleon that are closer to the “peak” of the binding energy graph near 56. Sometimes neutrons are also produced. This decomposition of a large nucleus into smaller pieces is called fission. The breaking is rather random with the formation of a large...
12.5K

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関連する実験動画

Updated: Feb 8, 2026

Production of Synthetic Nuclear Melt Glass
04:36

Production of Synthetic Nuclear Melt Glass

Published on: January 4, 2016

9.9K

内核膜は,核脂質滴を生成する代謝的に活発な領域である.

Anete Romanauska1, Alwin Köhler1

  • 1Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter Campus (VBC), Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria.

Cell
|June 26, 2018
PubMed
まとめ

内核膜 (INM) は脂質を活発に代謝し,貯蔵のための核脂質滴を形成する. この発見は核膜代謝とゲノム調節を結びつけ,ヒトの脂質消化症の研究に影響を与える可能性がある.

科学分野:

  • 細胞生物学
  • 分子生物学
  • 生物化学

背景:

  • 内核膜 (INM) は,ゲノムを包み込む核膜の一部である.
  • 外核膜 (ONM) は,脂質合成ハブであるエンドプラズマ網 (ER) に接続する.
  • ERとONMと比較して,INMの代謝機能は十分に理解されていません.

研究 の 目的:

  • 内核膜 (INM) の代謝能力を調査する.
  • 脂質代謝と貯蔵におけるINMの役割を調査する.
  • 核脂質滴の形成の調節とそのゲノム調節との関連を理解する.

主な方法:

  • モデル生物としてSaccharomyces cerevisiae (S. cerevisiae) を利用した.
  • 脂質代謝のためのINMを標的とした特定された酵素.
  • 核脂質滴と関連する膜ブリッジの形成と機能を調査した.
  • 核脂質の合成を制御する 遺伝子回路を分析した
  • 核脂滴による転写因子の封じ込めを調べた.

主要な成果:

  • INMは脂質の代謝と貯蔵に 適していることが示された.
キーワード:
リピンセイピンディアシルグリセロールエンドプラズマの網膜内核膜脂質代謝脂質センサー核脂肪酸の滴リン酸転写因子

さらに関連する動画

Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins
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Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins

Published on: August 10, 2014

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Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

10.7K

関連する実験動画

Last Updated: Feb 8, 2026

Production of Synthetic Nuclear Melt Glass
04:36

Production of Synthetic Nuclear Melt Glass

Published on: January 4, 2016

9.9K
Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins
10:03

Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins

Published on: August 10, 2014

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Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

10.7K
  • S. cerevisiaeがINMから核脂質を合成することを示した.
  • 脂質交換に関与するセイピン依存性膜ブリッジを特定した.
  • 核脂肪酸の合成を制御する 遺伝的回路を発見した
  • 核の脂質滴が 転写因子を隔離することで この回路を調節することを明らかにしました
  • 結論:

    • 内核膜 (INM) は適応性のある脂質代謝活動を有する.
    • 核脂滴の形成はINM代謝とゲノム調節に関連しています.
    • この発見は,ヒトの脂質消化症と核ゲノム相互作用の理解に意味を持つ.