関連する実験動画

Updated: Feb 8, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

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高速のフォーク進行はDNA複製のストレスとゲノム不安定を引き起こします

Apolinar Maya-Mendoza1, Pavel Moudry2,3, Joanna Maria Merchut-Maya2

  • 1Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark. apomm@cancer.dk.

Nature
|June 29, 2018
PubMed
まとめ

ポリ・・・ADP-リボース) ポリメラーゼ (PARP) の阻害は,DNA複製のフォーク速度を加速し,DNA損傷とゲノム不安定性を引き起こします. この発見は,複製のストレスを引き起こす重要なメカニズムとして,加速されたフォークの進行を明らかにします.

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