関連する実験動画

Updated: Feb 8, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

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REST の代替スプライシング依存制御の欠陥は,聴覚障害を引き起こす

Yoko Nakano1, Michael C Kelly2, Atteeq U Rehman3

  • 1Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Inflammation Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Cell
|July 3, 2018
PubMed
まとめ

REST遺伝子の代替スプライシングは 毛細胞のニューロンの遺伝子発現を制御することで 聴覚に不可欠です このスプライシングの欠陥はマウスとヒトで耳が聞こえない状態を引き起こしますが,HDAC阻害剤は潜在的な治療法を提供することができます.

キーワード:
DFNA27 についてNRSF についてREST について代替スプライシング頭毛細胞聴覚障害遺伝子発現の調節ヒストンデセチラーゼ阻害剤内耳ベスティブル毛細胞

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

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