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アンジトミン生物合成における劇的な骨格の再編成の構造と計算の基礎

Yu Nakashima1, Takaaki Mitsuhashi1, Yudai Matsuda1,2

  • 1Graduate School of Pharmaceutical Sciences , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-0033 , Japan.

Journal of the American Chemical Society
|July 5, 2018
PubMed
まとめ

AndAは鉄 (II) /α-ケトグルタレットに依存する酵素で,複雑なブリッジリング構造を構築する. X線結晶学と計算的研究により このユニークな化学変化を可能にする 重要な残留物と形状の変化が明らかになりました

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