効率的な口腔排毒剤としての金属有機枠組
Sara Rojas1, Tarek Baati1,2, Leila Njim3
1Institut Lavoisier, CNRS UMR 8180, UVSQ , Université Paris-Saclay , 45 Av. Des Etats Unis , Versailles 78035 Cedex , France.
Journal of the American Chemical Society
|July 11, 2018
まとめ
新しい生物互換性のある金属有機フレームワーク (MOF) は,口腔の解毒剤として有望であることが示されています. この吸着剤は,サリシラートの吸収と毒性を著しく低下させ,毒性の治療により安全な治療法を提供します.
科学分野:
- 材料科学
- 毒理学について
- 薬理学について
背景:
- 毒害や誤った口腔中毒は 世界的に大きな健康問題を引き起こしています
- 現在の解毒療法では 効果が十分でないことが多いのです
- 毒性の管理に先端の経口吸着剤が必要である.
研究 の 目的:
- 経口の解毒剤として新しい生物互換性金属有機フレームワーク (MOF) を開発し,評価する.
- 初めて口服した後にMOFの in vivo 毒性および生物分布を調査する.
- 一般的な毒剤,特にサリシラートの胃腸吸収と毒性を減らすためのMOFの有効性を評価する.
主な方法:
- バイオコンパティブルな金属有機フレームワーク (MOF) の合成と特徴付け
- MOFの胃腸の安定性と薬剤吸収能力のインビトロ評価
- 経口投与後のサリシラート吸収と毒性の低下におけるMOFの有効性を評価するために動物モデルでのin vivo試験.
- 経口投与されたMOFの生物分布研究を含む毒性評価
主要な成果:
- 開発されたMOFは,9%未満の分解で例外的な胃腸の安定性を示しました.
- MOFの経口投与は,サリシラートの胃腸吸収と毒性を40倍以上減少させた.
- MOFは腸内浸透性が低く,in vivoでは安全性プロファイルが良好でした.
- MOF治療により,サリシラート過剰投与に関連した組織学的損傷が効果的に回避されました.
結論:
- この先駆的な生物互換性金属有機フレームワーク (MOF) は,毒性の管理のために非常に有効で安全な口服吸着剤を提示します.
- 薬剤の吸収と毒性を著しく減少させる能力と 安定性と安全性が併せて,解毒戦略における画期的な成果です.
- MOFベースの吸着剤に関するさらなる研究は,中毒と中毒の治療を進める大きな可能性を秘めています.
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