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Updated: Feb 7, 2026

DNA Polymerase Activity Assay Using Near-infrared Fluorescent Labeled DNA Visualized by Acrylamide Gel Electrophoresis
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DNAポリメラーゼ θは,ポリメラーゼとライアゼの活動に共通の活性部位を使用する

Daniel J Laverty1, Ifor P Mortimer1, Marc M Greenberg1

  • 1Department of Chemistry , Johns Hopkins University , 3400 North Charles Street , Baltimore , Maryland 21218 , United States.

Journal of the American Chemical Society
|July 13, 2018
PubMed
まとめ

DNAポリメラーゼ θ (Pol θ) は,がんにおいて上位調節され,ポリメラーゼとライアゼの両方の活動に不可欠な鍵となるリジン残留物 (Lys2383) を有しており,抗がん薬の開発に潜在的な標的を提供している.

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