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Updated: Feb 7, 2026

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test
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人間のcGAS-DNA複合体の構造は,免疫監視の強化制御を明らかにする

Wen Zhou1, Aaron T Whiteley1, Carina C de Oliveira Mann1

  • 1Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Cell
|July 16, 2018
PubMed
まとめ

ヒトのサイクルGMP- AMP合成酵素 (cGAS) はDNAによって活性化されますが,ヒトのcGASは特定のDNA長さの検出により活性性が低下しています. この研究は,DNAの特異性を高めるために重要なヒトcGAS適応を明らかにしています.

キーワード:
スティングcGAS について生まれつきの免疫構造生物学

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