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Updated: Feb 7, 2026

Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models
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Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models

Published on: October 22, 2012

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メガカリオサイト性白血病 1 マクロファージにおけるNADPH酸化酵素のエピジェネティック活性化から心臓発血性損傷への橋渡し

Liming Yu1, Guang Yang1, Xinjian Zhang1

  • 1Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, China (L.Y., G.Y., X.Z., Z.L., M.F., Y.X.).

Circulation
|July 19, 2018
PubMed
まとめ

メガカリオサイト性白血病1型 (MKL1) は,マクロファージにおけるNADPH酸化酵素 (NOX) を表遺伝的に活性化することによって,心筋缺血再注射 (IR) 損傷を誘発する. MKL1- MOF- NOX経路を阻害することで,ROSを減少させ,心臓をIR損傷から保護します.

キーワード:
エピジェネティクスイシュミア・リパーフュージョンによる損傷反応性酸素種トランスクリプション・レギュレーター

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