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Updated: Feb 7, 2026

Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes
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53BP1-RIF1-シールドインは,CSTおよびPolα依存のフィールインを通じてDSB切除に対抗する

Zachary Mirman1, Francisca Lottersberger1,2, Hiroyuki Takai1

  • 1Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY, USA.

Nature
|July 20, 2018
PubMed
まとめ

CTC1-STN1-TEN1 (CST) 複合体は,ポリメラーゼアルファと作用し,切除を防ぐことによってDNAの二重鎖破裂修復を制御する. このメカニズムは,BRCA1変異性がんにおいて極めて重要です.

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