甲状腺のタフト細胞は,IL-4を濃縮した髄を促進し,甲状腺細胞の発達を形作る
Corey N Miller1,2, Irina Proekt1,2, Jakob von Moltke2,3,4,5
1Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Nature
|July 20, 2018
まとめ
研究者達は,T細胞の発達に不可欠な, 胸腺の細胞のサブセットを発見しました. 味覚経路とIL-25を表現するこれらの特化した細胞は,胸膜の微小環境を形成し,不変の自然キラーT細胞の成熟をサポートします.
科学分野:
- 免疫学
- 細胞生物学
- 発達生物学
背景:
- 甲状腺はT細胞を生成し,髄膜上皮細胞 (MECs) は自己耐性において重要な役割を果たします.
- 最近の研究では,これまで考えられていたよりもMEC内の異質性が大きいことが示唆されています.
研究 の 目的:
- 甲状腺髄の新種の表皮部分の特徴を特定する
- 胸膜の微小環境の形成におけるこのサブセットの機能と発展を調査する.
主な方法:
- 特定の上皮細胞サブセットの詳細な特徴.
- 味覚伝達経路とサイトカインを含む遺伝子発現の分析
- T細胞の発達における発達的依存性と機能的役割の調査
主要な成果:
- 味覚伝達経路とIL-25を表現するチムスタフト細胞のサブセットの特定
- これらの細胞は角状の集合体と結合し,抗原を提示し,様々な味覚受容体を発現する.
- TRPM5は彼らの機能に不可欠であり,不変の天然キラーT細胞の発達と骨髄におけるIL-4濃縮をサポートします.
結論:
- 独特の特徴と機能を持つ 胸膜タフト細胞の特殊なサブセットが存在します
- このサブセットは,分割された髄膜環境を確立する上で非冗長な役割を果たします.
- その分化が胸膜の機能,特に不変の自然殺傷性T細胞の発達を形作る上で極めて重要です.
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