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Updated: Feb 7, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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領域に焦点を当てたCRISPRスクリーンは,ヒトの赤血球細胞における胎児のヘモグロビン調節体としてHRIを識別する

Jeremy D Grevet1,2, Xianjiang Lan1, Nicole Hamagami1

  • 1Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|July 21, 2018
PubMed
まとめ

研究者達は,HRI (血液調節阻害剤) を,成人における胎児のヘモグロビン (HbF) の主要な抑制剤として特定した. HRIを阻害すると,HbFの生成が増加し,状細胞病とβ-タラセミアの新たな治療法となる可能性があります.

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