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新生猪の心臓の再生能力
Wuqiang Zhu1, Eric Zhang1, Meng Zhao1
1Department of Biomedical Engineering, School of Medicine, and School of Engineering (W.Z., E.Z., M.Z., C.F., Y.T., J.D.H., A.V.B., G.P.W., G.Q., J.Z.), University of Alabama at Birmingham.
Circulation
|July 22, 2018
まとめ
新生児の豚は 生後2日以内に心筋を再生できます この心臓の再生能力は心臓肌細胞の増殖と関連しており,出生後すぐに失われます.
科学分野:
- 心血管研究
- 新生児生理学
- 再生医療
背景:
- 歯類の心臓は 産後7日間の心筋再生を示します
- 大型の哺乳類における心筋再生の可能性は不明である.
研究 の 目的:
- 新生の大型哺乳類における心筋再生の窓を調査する.
- 新生児の豚が心筋梗塞の後に心臓の再生能力を示すかどうかを判断する.
主な方法:
- 生後数日の新生児の急性心筋梗塞 (AMI) (P1, P2, P3, P7, P14)
- 心臓のシストリック機能,心筋細胞循環活動,心臓発作の大きさ,テロメラーゼの活性が評価された.
- エコカルディオグラフィーと組織学的分析を用いて,AMIの30日後に評価された結果.
主要な成果:
- P1 群ではシストリック機能の回復が顕著で,P2 群ではAMI の30日後に部分的に回復した.
- 生後3日またはそれ以降にAMIが誘発されたとき,シストリック機能の障害が観察されました.
- P1心臓は,AMI後の傷痕が最小で,心筋細胞サイクル活動が増加した.
結論:
- 新生児の豚の心臓は,生命の最初の2日以内にAMI後に再生することができます.
- 心筋細胞の増殖が この再生能力の基礎です
- 生後すぐに心臓肌細胞が細胞サイクルを終了するので再生は失われます.
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