KCC2操作による損傷した脊髄における休眠状態のリレー経路の再活性化
1F.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Cell
|July 24, 2018
まとめ
KCC2アゴニストは,休眠状態のリレー回路を強化することで,脊髄損傷のマウスの歩行能力を回復させた. これは,KCC2アゴニストが脊髄損傷後の機能回復を促進することを示唆しています.
科学分野:
- 神経科学
- 脊髄損傷に関する研究
- 分子医学
背景:
- 多くの脊髄損傷は不完全ですが 完全な麻痺を引き起こします
- 保存された軸索が機能を回復できない理由は不明です.
- 怪我後の腰椎にリレー回路がある.
研究 の 目的:
- 脊髄損傷後の機能回復を媒介できない原因を調査する.
- 機能的回復を促進するための治療目標を特定する.
主な方法:
- 小分子スクリーンは,両側半断面を散らばったマウスで.
- 歩行能力の回復による 機能回復の評価
- KCC2と阻害性内ニューロンの役割を調査した.
主要な成果:
- KCC2アゴニストはマウスの歩行能力を回復させた.
- 抑制性インターニューロンにおける選択的KCC2発現または高極化DREADDは,この効果を模倣した.
- 治療は機能不全の脊髄回路を 機能状態に変えて 下降インプットリレーを 促進しました
結論:
- 脊髄阻害内ニューロンは 怪我後の下降インプットを統合する障壁として作用します
- KCC2アゴニストは,脊髄損傷後の機能回復を促進することを約束しています.
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