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Updated: Feb 7, 2026

Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution
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誘導進化によるバイオカタリシスバイエル=ヴィリゲル反応における従来の電子効果の優位性

Guangyue Li1,2,3, Marc Garcia-Borràs4, Maximilian J L J Fürst5

  • 1State Key Laboratory for Biology of Plant Diseases and Insect Pests/Key Laboratory of Control of Biological Hazard Factors (Plant Origin) for Agri-product Quality and Safety, Ministry of Agriculture , Institute of Plant Protection, Chinese Academy of Agricultural Sciences , Beijing 100081 , China.

Journal of the American Chemical Society
|July 26, 2018
PubMed
まとめ

研究者は,化学反応における地域選択性を逆転させるため,バイエル・ヴィリガー単酸化酵素 (BVMOs) を設計した. 誘導進化は酵素の好みを正常から異常な産物形成に切り替え,有機合成に対する新たな制御を提供した.

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