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Updated: Feb 7, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

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溶媒ネットワーク 拡張タンパク質結合部位におけるオリゴサカリド複合体の熱力学

Sonja Kunstmann1,2, Ulrich Gohlke3, Nina K Broeker1

  • 1Physikalische Biochemie , Universität Potsdam , Karl-Liebknecht-Str. 24-25 , 14476 Potsdam , Germany.

Journal of the American Chemical Society
|July 26, 2018
PubMed
まとめ

溶媒の影響により,タンパク質とグリカンの相互作用を理解することは困難です. この研究は,E. coliの特定のポケット (TSP) の水分子が,大きな結合部位においてさえ,結合熱力学に決定的な影響を及ぼすことを明らかにしています.

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