熱帯病に対する薬の発見における課題と最近の進展

Manu De Rycker¹, Beatriz Baragaña¹, Suzanne L Duce²

¹Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.

Nature

|July 27, 2018

まとめ

高い死亡率と経済的影響のために熱帯感染症の新薬の開発は極めて重要です現在の治療法は不十分で効果的な治療法の研究と開発が急務です

科学分野:

熱帯医学
感染症
薬物開発

背景:

感染性熱帯病は深刻な死亡率や病率や経済的負担を引き起こし,貧困層に不釣り合いな影響を及ぼします
現存する医薬品の介入はこれらの一般的な病気の多くには不十分です
これらの軽視された病気と闘うために新種の治療薬が必要なのです

研究の目的:

熱帯感染症の新薬開発に伴う課題を検討する.
この分野における最近の進歩を強調する.
革新的な治療戦略の継続的な必要性を強調する

主な方法:

熱帯病の治療における現在の研究開発に関する文献レビュー.
薬の発見と臨床翻訳における障害の分析
この分野における最近の成功と残る障害をまとめます.

主要な成果:

熱帯病の新薬の開発には大きな課題が残っている.
最近は進展がみられたが,現在の能力と治療の必要性との間に大きなギャップが残っている.
経済的負担と健康への影響は継続的なイノベーションの緊急性を強調しています

結論:

熱帯感染症の有効な治療法の開発は顕著な成功にもかかわらず複雑で長いプロセスです
既存の課題を克服し,必要不可欠な治療法を提供するために,継続的な投資と研究が不可欠です.
世界的な健康と経済への影響に対処するには薬剤の発見と開発の継続的な努力が必要です

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