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Insulin: The Receptor and Signaling Pathways01:28

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Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
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インスリン信号の社会的調節とアリにおけるユーソシアリティの進化

Vikram Chandra1, Ingrid Fetter-Pruneda1, Peter R Oxley2,3

  • 1Laboratory of Social Evolution and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. vchandra@rockefeller.edu ifetter@rockefeller.edu dkronauer@rockefeller.edu.

Science (New York, N.Y.)
|July 28, 2018
PubMed
まとめ

研究 者 たち は,インスリン の よう な ペプチド 2 (ILP2) 遺伝子 が アリ の 生殖 部門 の 働き を 制御 し て いる こと を 発見 し まし た. ILP2レベルを操作することで 社会的構造を活性化したり安定させたりし ユーソシアリティの進化の洞察を得ることができます

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科学分野:

  • 進化生物学
  • 分子内分泌学
  • 社会的な昆虫の行動

背景:

  • アリのような社会的な昆虫の 生殖分工の進化は 生物学の重要な問題です
  • 現存する理論は,祖先のサブ社会的ライフサイクルフェーズとの同質性を示唆しているが,分子基盤は不明である.

研究 の 目的:

  • アリの繁殖分工を制御する 分子機構を特定する
  • アリの社交性と生殖サイクルにおけるインスリン類似ペプチド2 (ilp2) の役割を調査する.

主な方法:

  • 候補遺伝子を特定するために脳トランスクリプトミクススクリーン.
  • 繁殖と非繁殖におけるインスリン類似ペプチド2 (ilp2) の遺伝子発現分析
  • クローンレイダーアリ (Ooceraea biroi) のILP2ペプチドレベルを実験的に操作する.

主要な成果:

  • インスリン類似ペプチド2 (ilp2) 遺伝子は,潜在的により良い栄養により,アリの繁殖において一貫して上位調節された.
  • Ooceraea biroiの幼虫信号は,ilp2を阻害することによって,成人生殖を抑制し,サブ社会的サイクルを作成します.
  • ILP2のレベルが上昇すると,幼虫の抑制を回避し,安定した生殖分業を確立します.

結論:

  • 幼虫のシグナルによって増幅される栄養による生殖の違いは,アリの優社会性の起源の単純なモデルである可能性があります.
  • インスリンのようなペプチド2 (ILP2) は,生殖状態と社会的構造を調節する重要な分子スイッチとして作用します.
  • この発見は,アリにおける安定した生殖カスタの進化の潜在的メカニズムを提供する.