19F H2O2とペロキシダースの活性に対する磁気共振探知器
Meng Yu1, Bailey S Bouley1, Da Xie1
1Department of Chemistry , University of Texas at Austin , Austin , Texas 78712-1224 , United States.
Journal of the American Chemical Society
|July 28, 2018
まとめ
新しいコバルト複合体は,フッ素-19磁気共鳴画像 (MRI) を使用して,炎症に関連する酸化ストレスを検出します. これらの薬剤は,活性酸素種と過酸化酵素の活性をターゲットに可視化し,炎症性疾患の新しい診断ツールを提供します.
科学分野:
- バイオメディカルイメージング
- 化学生物学
- 材料科学
背景:
- 反応性酸素種 (ROS) と過酸化酵素の活動は,炎症および炎症性疾患の主要な指標です.
- 炎症を診断する現在の方法は,特異性と感度が限られている.
研究 の 目的:
- 19F磁気共鳴画像 (MRI) を使用して炎症に関連した酸化活動を検出するための新しいコバルト (II) コンプレックスを開発する.
- 酸化出来事を選択的に視覚化し,過酸化水素の産生と過酸化酵素の活性を区別する.
主な方法:
- 2つの新しい Co ((II) 複合体の合成と特徴付け
- 化学的シフト選択パルス配列による19FMRIを用いて,酸化および還元された形態の薬物を視覚化します.
- H2O2と過酸化酵素に対する複合体の異なる反応性を調査する.
主要な成果:
- 開発されたCO2複合体はCO2に酸化すると19Fの化学変化が顕著である.
- この大きな化学的シフトは,高スピンCo ((II) 磁性アニソトロピーに起因し,選択的なイメージングを可能にします.
- この2つの薬剤は異なる反応性を示し,H2O2または過酸化酵素の活性を検出することができます.
結論:
- 新規のCo ((II) コンプレックスは,炎症における酸化現象の19FMR"ホットスポット"イメージングの効果的なプラットフォームとして機能する.
- これらの薬剤は,炎症に関連する酸化ストレスを早期に選択的に検出するための有望なアプローチを提供します.
- 双剤系は,炎症過程におけるROSと酵素の複雑な相互作用を研究するための汎用的なツールを提供します.
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