マルチヘム・サイトクローム・メディアド・レドックス・コンダクション Shewanella oneidensis MR-1 細胞を通して
Shuai Xu1, Alexandre Barrozo2, Leonard M Tender3
1Department of Physics and Astronomy , University of Southern California , Los Angeles , California 90089 , United States.
Journal of the American Chemical Society
|July 31, 2018
まとめ
Shewanella oneidensis MR-1細胞は,細胞外電子移転 (EET) のためにマルチヘム・サイトクロームを使用する. 微生物の電子輸送に不可欠なMtr経路による酸化還元伝導を 電気化学測定で明らかにした.
科学分野:
- 微生物学
- バイオ物理学
- 電気化学
背景:
- マルチヘム・サイトクロームは微生物の細胞外電子伝達 (EET) を促進する.
- これらのタンパク質は微生物の代謝と固体表面との相互作用に不可欠です.
- 細胞内および細胞間での長距離電子伝送にも関与しています.
研究 の 目的:
- Shewanella oneidensis MR-1細胞における電子輸送のメカニズムを調査する.
- Mtr経路におけるマルチヘム・サイトクロームの機能と電気化学的測定を関連付ける.
- これらの微生物系における電子輸送の熱活性化エネルギーを決定する.
主な方法:
- 電気化学ゲート測定はShewanella oneidensis MR-1細胞で行われました.
- 細胞は電子同士で繋がっていた.
- ゲートポテンシャルに対するソース・ドレイン電流の依存性が分析された.
- 電子のジャンプ計算を用いて,Mtr細胞染色体を通過する輸送をモデル化した.
主要な成果:
- 電気化学ゲーティングは,S. oneidensis MR-1細胞における酸化還元伝導機構を示した.
- この伝導はMtr経路のマルチヘム・サイトクロームに起因する.
- 測定された熱活性化エネルギー (0.29 ± 0.03 eV) は,Mtr外膜細胞染色体を通過する電子ジャンプの計算と一致する.
結論:
- S. oneidensis MR-1 のマルチヘム・サイトクロームは,レドックスベースの電子伝導を媒介する.
- この微生物の細胞外電子伝達にはMtr経路が不可欠です
- 微生物系における電子輸送に関する洞察を 提供しています
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