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Updated: Feb 7, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

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RNA依存性エピジェネティック・サイレンシングは,イントロニック・リピート・エクスパンションによって引き起こされる転写下調を誘導する

Hannes Eimer1, Sridevi Sureshkumar1, Avilash Singh Yadav1

  • 1School of Biological Sciences, Monash University, Clayton Campus, VIC 3800, Australia.

Cell
|July 31, 2018
PubMed
まとめ

三重の繰り返し拡張は短い干渉RNA (siRNA) と表遺伝的変化を誘発し,遺伝子の静止を引き起こします. RNA依存性DNAメチル化 (RdDM) を含むこのメカニズムは,これらの拡張が病気の表型を引き起こす方法を説明します.

キーワード:
アラビドプシスフライドライヒス・アタクシアRdDM経路についてエピジェネティック・サイレンシングsiRNAs についてトランスクリプションダウンレギュレーション三重の繰り返し拡張

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