脊椎動物のニューラル・クライストと頭蓋骨のプラコッドの共同進化起源
Ryoko Horie1, Alex Hazbun1,2, Kai Chen1
1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Nature
|August 3, 2018
まとめ
脊椎動物シオナ・インテスティナリスの側板外皮は,脊椎動物に似た区画化を示している. これは この古代のシステムから プラコードと 神経頂部細胞の 共通の進化的起源を示唆しています
科学分野:
- 発達生物学
- 進化生物学
- 遺伝学
背景:
- プラコーダとニューラル・クライストは脊椎動物の重要な特徴ですが,その進化的関係は不明です.
- 脊椎動物の進化における側板エクトダームの役割は,さらなる調査を必要としています.
研究 の 目的:
- 原脊椎動物シオナ・インテスティナリスの 側板エクトダームの性質を調査する.
- プラコードとニューラル・クライストの 進化的起源を探るため
主な方法:
- 血統追跡
- 遺伝子破壊試験
- 単細胞RNAシーケンシング (scRNA-seq)
主要な成果:
- シオナの側板エクトドームは脊椎動物の神経板エクトドームと類似している.
- Six1/2,Pax3/7, Msxbを含む 制御ネットワークが 細胞の運命を制御しています
- 遺伝的障害により 双極性尾神経細胞 (ニューラル・クライストのような) が 触覚感覚細胞 (プラコードのような) に変化します
結論:
- 脊椎動物より前の 側板エクトダーマの区画化
- このシステムはおそらく頭蓋骨のプラコードと 神経頂部の進化の共通の源として機能した.
- この発見は脊椎動物細胞の 進化の歴史を深く洞察するものです
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