急性骨髄性白血病
Nicholas J Short1, Michael E Rytting2, Jorge E Cortes1
1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lancet (London, England)
|August 7, 2018
まとめ
最近の進歩により,急性骨髄性白血病 (AML) の新しい治療法とリスク評価が改善されています. しかし,患者のアウトカムは依然として不良であり,生存率をさらに改善するために新しい治療法と組み合わせの臨床試験が必要である.
科学分野:
- 血液学
- 腫瘍学
- ゲノミクス
背景:
- 急性骨髄性白血病 (AML) は 何十年にもわたって 治療の進展が限られている.
- 近年 (2017年以来) は,AML薬の承認と生物学的理解に大きな進歩を示しています.
- 治療の進展にもかかわらず,AMLの患者のアウトカムは依然として不満足で,死亡率は高い.
研究 の 目的:
- 急性骨髄性白血病の 最近の治療法と生物学的進歩を要約します
- AML治療の継続的な研究と臨床試験の必要性を強調する.
主な方法:
- AML薬の最近の規制承認のレビュー
- AMLの生物学とゲノム構造の理解の進化を分析する.
- 分子偏差を含む最新のリスク分層ガイドラインの検討
主要な成果:
- 2017年以来,AML治療に複数の新薬が承認されています.
- パーソナライズされた管理のための 分子偏差値を含む 精巧なリスク評価戦略です
- AML患者の半数以上は 病気に罹り続けています これは満たされていないニーズを示しています
結論:
- 急性骨髄性白血病の治療は 新しい治療法と診断ツールによって急速に発展しています
- AMLゲノミクスの理解を深めることは リスクに適応した戦略に役立ちます
- 臨床試験への参加は,新しい組み合わせを開発し,AMLにおける患者の生存率を改善するために不可欠です.
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