FOXP2における最近の人種選択の証拠はない
Elizabeth Grace Atkinson1, Amanda Jane Audesse2, Julia Adela Palacios3
1Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, USA.
Cell
|August 7, 2018
まとめ
FOXP2遺伝子は 人間の言語に不可欠で 最近の選択は示されていません 代わりに 保存された内部の領域は 機能の喪失を示唆し 進化の歴史を修正します
科学分野:
- 人類の進化
- 遺伝学
- 分子生物学
背景:
- FOXP2遺伝子は 人間の言語と進化に 関連しています
- 過去の研究では,ヒトにおけるFOXP2の最近の陽性選択が示唆された.
- これは古代ヒトの FOXP2 置換の発見と矛盾している.
研究 の 目的:
- 大規模で多様なゲノムデータセットで FOXP2を再分析する
- FOXP2で最近の陽性またはバランス選択をテストする.
- FOXP2の進化史を調査する
主な方法:
- 何百ものヒトゲノムにおける FOXP2の総合的な再分析
- 最近の陽性とバランス選択のテスト
- 保存とポリモルフィズムのための内部領域の分析.
- 遺伝子発現分析のためのRNAシーケンシング (RNA-seq) と逆転写PCR (RT-PCR).
主要な成果:
- FOXP2の最近の陽性またはバランス選択の証拠は見つかりませんでした.
- 最初の選択信号はサンプル組成に起因した.
- 機能の喪失を示唆する 高い保全とヒトのポリモルフィズムを示した
- この領域は人間の脳組織に低い表現を示した.
結論:
- FOXP2の適応歴は,大幅な修正を必要としています.
- 人間の進化における FOXP2 の役割は ポジティブな選択ではなく 機能の喪失を伴うかもしれません
- これらの発見は FOXP2が人間の言語進化の 重要な原動力であるという 既成説に異議を唱えるものです
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