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Updated: Feb 6, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

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サイト特異のインターフェロンαブロックコポリマーコンジュガートのポリメリゼーション誘導による自己組み立てが,薬理学的に顕著に改善されたミセルに

Xinyu Liu1, Mengmeng Sun1, Jiawei Sun1

  • 1Department of Biomedical Engineering, School of Medicine , Tsinghua University , Beijing 100084 , China.

Journal of the American Chemical Society
|August 8, 2018
PubMed
まとめ

局所特異的な局所ポリメリゼーション誘発セルフアセンブリ (SI-PISA) により,インターフェロン-α (IFN) 結合ミセルが生成された. これらのミセルはタンパク質の生物活性と in vivo 半減期を著しく高め,マウスの腫瘍を完全に抑制しました.

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