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Updated: Feb 6, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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人間のPKD1-PKD2複合体の構造

Qiang Su1, Feizhuo Hu1, Xiaofei Ge1

  • 1Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

Science (New York, N.Y.)
|August 11, 2018
PubMed
まとめ

自体主有多囊性腎疾患 (ADPKD) は,PKD1およびPKD2遺伝子変異と関連しています. 研究者はPKD1-PKD2複合体の構造を明らかにし,ADPKDの疾患メカニズムを説明できる非正規のTRPチャネルアーキテクチャを発見した.

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