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Updated: Feb 6, 2026

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プラズモジアム・プロテアソーム阻害剤の特異性の決定因子の定義

Euna Yoo, Barbara H Stokes, Hanna de Jong

  • 1Drug Discovery and Development Centre (H3D) , University of Cape Town , Rondebosch 7701 , South Africa.

Journal of the American Chemical Society
|August 16, 2018
PubMed
まとめ

新しい抗マラリア薬を開発した研究者は,高度に選択的なプラズモジアム・プロテアソーム阻害剤を特定しました. これらの化合物は,アルテミシニン (ART) ベースの治療法と相乗効果を示し,マラリア寄生虫の除去に有効です.

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The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
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Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
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The Proteasome02:18

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The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
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Psychology is the scientific discipline dedicated to understanding both observable behavior and the internal mental processes underlying such behavior. It aims to comprehend human nature and apply this understanding to solve practical problems, enhance well-being, and improve societal outcomes. An example of psychology's application is the study of prosocial behavior, such as why and under what conditions individuals might help strangers in need. This process involves describing observed...
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