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関連する概念動画

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アップコンバーティングナノ粒子で見る,ターゲットにする,配達する

Ghulam Jalani1, Vivienne Tam1, Fiorenzo Vetrone2

  • 1Department of Mining and Materials Engineering , McGill University , Montreal , Quebec H3A 0C5 , Canada.

Journal of the American Chemical Society
|August 17, 2018
PubMed
まとめ
この要約は機械生成です。

アップコンバーティングナノ粒子 (UCNP) は,近赤外線 (NIR) を使って,深層組織に発光された薬物の投与を可能にします. UV/Vis光の限界を克服し 精密で非侵襲的な治療法を適用できます

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科学分野:

  • ナノテクノロジーと生物医学工学
  • 光薬学と薬物投与システム

背景:

  • 効果的な薬剤の放出制御は,治療効果を高め,有害な影響を最小限に抑えるために不可欠です.
  • 現在の光触発薬剤投与システムは,UV/Vis光が組織に浸透し,毒性を引き起こす可能性が限られている.
  • アップコンバーティングナノ粒子 (UCNP) は,より深く浸透する近赤外線 (NIR) 光をより短い波長に変換することで解決策を提供します.

研究 の 目的:

  • UCNPベースの照明制御薬剤投与システムの最近の進歩をレビューする.
  • これらの技術の臨床翻訳のための課題を議論し,解決策を提案する.
  • 精密で非侵襲的な治療用途のためのNIR誘発UCNPの可能性を強調する.

主な方法:

  • 近赤外線 (NIR) を吸収するためにUCNPを使用します.
  • 吸収されたNIR光を 短波のUV,可視光,NIR放射に変換する.
  • 局所的な薬剤の放出と バイオイメージングを誘発するために

主要な成果:

  • UCNPは,UV/Vis光よりも深く組織に浸透するNIR光によって薬の放出を可能にします.
  • このアプローチにより 身体の特定の部位に 薬を正確に 要求に応じて投与できます
  • UCNPは,薬剤の放出とバイオイメージングの両方の有効なインサイト光源として機能します.

結論:

  • UCNP媒介のNIRトリガド・ドラッグ・デリバリー・システムは,従来の照明制御方法よりも重要な進歩を示しています.
  • これらのシステムは 麻酔薬,傷の治癒,手術,がんの治療に 有望な応用がある.
  • UCNPベースの薬物投与の臨床翻訳を容易にするためにさらなる研究と開発が必要である.