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Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
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Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events

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停止した転写複合体の構造 Pol II-DSIF-NELF

Seychelle M Vos1, Lucas Farnung1, Henning Urlaub2,3

  • 1Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen, Germany.

Nature
|August 24, 2018
PubMed
まとめ

研究者は,冷凍EMを用いて,一時停止したRNAポリメラーゼII (Pol II) を視覚化しました. 負の伸縮因子 (NELF) はPol IIの移動性を抑制し,転写の伸縮を防止し,遺伝子調節を一時停止する.

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