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Updated: Feb 6, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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RAP2はヒッポの経路のメカニカル反応を媒介する

Zhipeng Meng1, Yunjiang Qiu2,3, Kimberly C Lin1

  • 1Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.

Nature
|August 24, 2018
PubMed
まとめ

Rasに関連したGTPase RAP2は分子スイッチとして機能し,細胞外マトリックス硬度信号を伝達し,ヒッポの経路エフェクターYAPとTAZを通じて細胞の成長と遺伝子転写を制御します.

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