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Updated: Feb 6, 2026

A Two-interval Forced-choice Task for Multisensory Comparisons
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子宮頸がんのスクリーニング:米国予防サービスタスクフォースの勧告声明

, Susan J Curry1, Alex H Krist2,3

  • 1University of Iowa, Iowa City.

JAMA
|August 25, 2018
PubMed
まとめ

子宮頸がんのスクリーニングガイドラインは,21歳から3年ごとに細胞検査,または30歳から細胞検査,高リスクヒトパピローマウイルス (hrHPV) 検査,または3~5年に一度のコテスティングを推奨しています. 21歳未満または65歳以上の女性が適切なスクリーニングを受けた場合,スクリーニングは推奨されません.

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科学分野:

  • 腫瘍学
  • 予防 医療
  • 公衆衛生

背景:

  • 子宮頸がんの死亡率は 検診により減少しています
  • 米国予防サービスタスクフォース (USPSTF) は2012年の勧告を更新しました.
  • スクリーニング方法と間隔に関する証拠が検討された.

研究 の 目的:

  • 子宮頸がんのスクリーニングに関するUSPSTFの勧告を更新する.
  • 高リスクヒトパピローマウイルス (hrHPV) 検査と細胞検査を含むスクリーニング戦略を評価する.
  • 最適なスクリーニング年齢と間隔を決定し,利益と害を比較します.

主な方法:

  • 臨床試験とコホート研究の体系的レビュー
  • hrHPV検査のみ,細胞検査のみ,または併用検査によるスクリーニングの評価
  • スクリーニングパラメータと戦略のための意思決定分析モデリング.

主要な成果:

  • 検診は21歳から65歳の女性の 子宮頸がんの発生率と死亡率を低下させる.
  • 21歳から65歳の女性の場合,スクリーニングの利点が 害を上回ります.
  • サイトロジー単独 (21-29歳) とサイトロジー, hrHPV,またはコテスティング (30-65歳) の利益が害を上回る高い確実性.

結論:

  • 21~29歳の女性には 3年ごとに細胞検査を推奨する.
  • 30歳から65歳までの女性には,細胞検査で3年毎, hrHPVで5年毎,またはコテスティングで5年毎のスクリーニングを推奨します.
  • 21歳未満,65歳以上 (適切なスクリーニング),または前科で高度な病変がない子宮切除後の女性ではスクリーニングを推奨しない.