新生児の免疫システム発達のステレオタイプ

Axel Olin¹, Ewa Henckel², Yang Chen¹

¹Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, 17121 Solna, Sweden.

Cell

|August 25, 2018

まとめ

新生児の早期の免疫系の発達は,最初の3ヶ月以内に顕著な変化を示します. 微生物の相互作用が免疫の軌道を走らせますが腸の機能不全が阻害します

科学分野:

免疫学
新生児に関する研究
微生物群の研究

背景:

早期の暴露は免疫媒介性疾患に大きな影響を及ぼします
乳児は感染症に非常に敏感であり,早期の免疫発達に関する研究が必要である.
現在の研究では動物モデルや帯血を用いており産後環境の影響は捉えられません

研究の目的:

生後3ヶ月の新生児の免疫系発達を縦断的に分析する.
出生後の免疫細胞集団と血タンパク質の変化を特定する.
乳児の免疫経路に影響を与える要因を理解するために

主な方法:

最初の3ヶ月で100人の新生児から長距離採血 (最大4回)
58の免疫細胞集団の質量分析
血タンパク質267の免疫分析

主要な成果:

帯血のデータから予測できない劇的な,ステレオタイプの免疫系変化が観察されました.
時期を超えて収束する,早産および満期の乳児の出生時の独特の免疫プロファイルが特定されました.
微生物の相互作用が免疫の発達を促し腸の機能不全が障害となる可能性を示唆する証拠が見つかりました

結論:

新生児の免疫発達は,出産後の暴露によって影響される予測可能なパターンに従います.
乳児の免疫形成には微生物,特に腸内細菌が重要な役割を果たします
早期の腸内障害は免疫系の成熟に悪影響を及ぼす可能性があります.

キーワード:

CyTOF についてヒト免疫学免疫系の発達免疫の変化マスサイトメトリー新生児新生児科新生児の免疫系産前出産システム免疫学

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