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Updated: Dec 23, 2025

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System

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TBK1はRIPK1誘発のアポトーシスと発育期および老化期における炎症を抑制する

Daichao Xu1, Taijie Jin2, Hong Zhu1

  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.

Cell
|August 28, 2018
PubMed
まとめ

RIPK1を活性化するTAK1を減らし,老化が神経変異を悪化させる. TBK1の喪失のような遺伝因子との相互作用は 軟骨縮性側頭葉硬化症と 前頭葉性認知症を促します

キーワード:
ALS についてFTD についてRIPK1 についてRIPK1依存アポトーシスTAK1 についてTBK1 についてカスパースネクロプトーシス

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