解剖学的に定義され,機能的に区別される脊椎ラフェセロトニンサブシステム

Jing Ren¹, Drew Friedmann¹, Jing Xiong²

¹Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Cell

|August 28, 2018

まとめ

背面ラフェ (DR) セロトニンシステムは単一の単位ではありません. 異なるDRニューロン集団が異なる脳の領域に広がり不安や対処行動に影響します

科学分野:

神経科学
神経生物学
セロトニン系

背景:

背中のラフェ (DR) は前脳のセロトニンの主要な源です.
気分や不安運動機能に影響します
以前の研究では,DRセロトニンニューロンを均一な集団として扱った.

研究の目的:

DRセロトニンニューロンの機能的異質性を調査する.
下皮質と皮質に発射するDRセロトニンニューロン集団を区別する.

主な方法:

ウイルスの遺伝子追跡技術が採用された.
膀性グルタミン酸トランスポーターの共表現の分析
全脳裏付けのマッピング
プレシナプス入力に関する調査
機能の獲得と喪失の実験

主要な成果:

下皮質と皮質を投射するDRセロトニンニューロンは,異なる分布と共表現パターンを示しています.
アミグダラと前頭皮質を投影するニューロンは互いを補完する接続性と偏った入力を示します
これらの異なる集団は嫌悪的な刺激に対して逆の反応をする.
アミグダラ発射ニューロンは不安を促し前頭皮質発射ニューロンは積極的な対処を促します

結論:

DRセロトニンシステムは,平行で機能的に異なるサブシステムで構成されています.
これらのサブシステムは,接続性,応答特性,および行動的役割によって異なります.
この発見はセロトニンが脳機能と行動に果たす役割についての理解を洗練しています

キーワード:

5-HT について Tph2 について Vglut3 について心配する中枢桃体うつ病背面ラフェファイバーフォトメトリー iDISCO (アイディスコ)軌道前頭皮質セロトニン

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