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Updated: Feb 6, 2026

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NORAD lncRNAは,ゲノム安定性にとって重要なトポイソメラーゼ複合体を組み立てる

Mathias Munschauer1, Celina T Nguyen2, Klara Sirokman2

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA. mathias@broadinstitute.org.

Nature
|August 29, 2018
PubMed
まとめ

長い非コーディングRNAのNORADは,RBMXを結合して,TOP1とPRPF19-CDC5Lを含むNARC1複合体を形成することで,ゲノム安定性を維持する. この相互作用はDNA修復と染色体不安定性の予防に不可欠です

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