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Updated: Feb 5, 2026

A Method to Study de novo Formation of Chromatin Domains
07:34

A Method to Study de novo Formation of Chromatin Domains

Published on: August 23, 2019

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病気に関連した短いタンデムリピートは,クロマチン領域の境界と同局する

James H Sun1, Linda Zhou2, Daniel J Emerson3

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Cell
|September 4, 2018
PubMed
まとめ

3Dクロマチン領域の境界で,疾患に関連した短いタンデムリピート (STR) が発見される. これらの部位,特に高CpG密度部位は,フレージルX症候群のような反復膨張障害を理解する鍵となる可能性があります.

キーワード:
3Dゲノム折りTADs について脆弱なX症候群ゲノムの不安定性高次クロマチン構造短時間タンデムリピートサブTADsトポロジカルな関連ドメイントリヌクレオチド重複膨張障害

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