前がん性腫瘍細胞は,管系を通過することができます
Alvin P Makohon-Moore1, Karen Matsukuma2, Ming Zhang3
1The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nature
|September 5, 2018
まとめ
臓がんの進行には,長年にわたって進化する前身の病変が含まれます. 遺伝子分析では 一つの臓の 独特な病変は 管道系に侵入した 単一の腫瘍に起因します
科学分野:
- 腫瘍学
- 遺伝学
- 進化生物学
背景:
- 大人のがんのほとんどは 非侵襲的な前駆体病変から生じる.
- 併存した病変の進化的・遺伝的関連は 十分に理解されていない.
研究 の 目的:
- 同じ臓内の臓がんとその前身の病変の進化的および遺伝的関係を調査する.
- 臓がんの段階的な進行モデルを再考する
主な方法:
- 臓がんの体内変異と,特定の臓部位からの前駆体病変の分析
- 病変の進化的関係を推論する.
主要な成果:
- 祖先の細胞が 複製して広がり 複数の病変を 生み出したことを確認しました
- その後 駆動遺伝子の変異により 侵襲的な臓がんが長年にわたって発生しました
- 単一の臓の 明確な高度の前駆体損傷は しばしば単一の腫瘍を代表し 管道系を植民地化しています
結論:
- 臓がんは長期間,多段階の進行を経て発症する.
- 一つの臓内の独立した前駆体病変は,共通の腫瘍源から発生する可能性があります.
- この研究は 臓がんの進化と空間的遺伝的差異の理解を 再構築するものです
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