パーソナライズされた腸内粘膜コロニゼーション 経験的なプロバイオティクスの耐性は,ユニークな宿主と微生物群の特徴と関連している
Niv Zmora1, Gili Zilberman-Schapira2, Jotham Suez2
1Immunology Department, Weizmann Institute of Science, Rehovot, 7610001, Israel; Internal Medicine Department, Tel Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel.
Cell
|September 8, 2018
まとめ
プロバイオティクスは 消化に耐えながらも 抵抗性のせいで 腸内膜に侵入するのは困難です 効果的な腸内微生物群と健康への影響には パーソナライズされたプロバイオティクスの戦略が必要です
科学分野:
- 胃腸内科
- 微生物群の研究
- 免疫学
背景:
- プロバイオティクスは健康のために広く使用されていますが 腸内コロニー化の有効性は議論されています
- 腸内粘膜とプロバイオティクスの相互作用を理解することは 腸内粘膜とプロバイオティクスの相互作用を理解することは 腸内粘膜とプロバイオティクスの相互作用を理解することは 腸内粘膜とプロバイオティクスの相互作用を理解することは 腸内粘膜とプロバイオティクスの相互作用を理解することは 腸内粘膜とプロバイオティクスの相互作用を理解することは 腸内粘膜とプロバイオティクスの相互作用を理解することは
研究 の 目的:
- マウスとヒトの腸内粘膜のプロバイオティクスの有効性を調査する.
- 腸内微生物と宿主トランスクリプトームに対するプロバイオティクスの影響を特徴づける.
主な方法:
- ネズミとヒトの粘膜関連および便の微生物群のメタゲノミクス分析.
- プロバイオティクスの摂取またはプラセボの摂取中の侵入性マルチオミック測定
- 細菌のないマウスのコロニー化抵抗性の比較
主要な成果:
- プロバイオティクスは胃腸経路を通過した後も有効でした.
- 植民されたマウスはプロバイオティクスの 重要な粘膜植民抵抗性を示した.
- ヒトの粘膜の植民地化パターンは人,地域,株に特異的でした.
- プロバイオティクスは 粘膜のコミュニティ構造と腸のトランスクリプトームに 暫定的な個別化された効果を誘発した.
結論:
- 経験的なプロバイオティクスのサプリメントは,腸内粘膜に普遍的で持続的な影響を及ぼしています.
- パーソナライズされたプロバイオティクスのアプローチは有効性を高めるために必要である.
- ベースラインの宿主と微生物群の特徴は プロバイオティクスのコロニー化パターンを予測します
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