視覚皮質と海馬における主観的な空間位置の一貫したエンコーディング
Aman B Saleem1,2, E Mika Diamanti3,4, Julien Fournier3
1UCL Institute of Ophthalmology, University College London, London, UK. aman.saleem@ucl.ac.uk.
Nature
|September 12, 2018
まとめ
マウスの視覚皮質 (V1) のニューロンは空間的調節を示し,ナビゲーション信号が初期の感覚処理に影響を与えることを示している. これらの信号は,海馬のナビゲーション表現と整合し,主観的な位置推定を反映します.
科学分野:
- 神経科学
- 計算神経科学
- 感覚 処理
背景:
- 視覚とナビゲーションの脳のシステムが 相互に繋がっているため 視覚は航海に不可欠です
- 以前の研究では 空間的な位置信号は 視覚野の初期に発生すると示唆されていました
研究 の 目的:
- 主要視野皮質 (V1) の空間信号の性質を調査する.
- これらの信号は,ナビゲーション情報と主観的な位置推定によって調節されているかどうかを判断する.
主な方法:
- ネズミのV1と海馬のCA1のニューラル活動が 仮想現実の廊下で記録されました
- 空間的な反応から視覚的な反応を区別するために,異なる場所の同一の視覚的なランドマークを使用しました.
- マウスを訓練して 特定の場所と 水の報酬を結びつけ 主観的な位置を推測します
主要な成果:
- 大半のV1ニューロンは空間的調節を示し,位置によって同一の視覚的地標に異なった反応を示した.
- V1とCA1の両方のニューラル集団は,動物の位置と相関する表現エラーをエンコードしました.
- V1とCA1の両方の表現は,実際の位置よりも,動物の主観的な位置 (する行動から推測された) をよりよく反映した.
結論:
- V1の視覚反応は,ナビゲーション信号によって大きく影響されます.
- V1のこれらのナビゲーション信号は,海馬の信号と一致し,動物の主観的な空間的意識を反映しています.
- 発見は,ナビゲーション情報が 初期の皮質領域から 感覚処理に浸透することを示唆しています.
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