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検出可能な全ゲノムオフターゲットの変異なしの in vivo CRISPR 編集

Pinar Akcakaya1, Maggie L Bobbin2,3,4, Jimmy A Guo2,3

  • 1Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Nature
|September 14, 2018
PubMed
まとめ

新しい方法である in vivo off-targets (VIVO) の検証は,信頼性の高い CRISPR-Cas off-target 変異を in vivo で検出します. VIVOは遺伝子編集が マウスの肝臓で安全で効果的であることを示しています

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