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触覚や触覚神経疾患の痛みの感受性は,皮質脊髄の投影によって決定される
Yuanyuan Liu1,2, Alban Latremoliere1,3, Xinjian Li4,5
1F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
Nature
|September 14, 2018
まとめ
脳について
科学分野:
- 神経科学
- ソマトセンサーシステム
- 痛みの知覚
背景:
- 伝統的なモデルでは 脳の感覚経路が 向上していることに焦点を当てています
- 認知に対する上から下への精神的影響は脳局所的なものと考えられています
- 脊髄皮質 (CST) は主に運動経路である.
研究 の 目的:
- 脊髄の感覚処理の 直接的な上下皮質制御を調査する
- 体感覚知覚における CST の役割を探求する.
- 触覚性アロディニアの 神経機構を理解する
主な方法:
- ソマトセンサリー皮質に由来する皮質脊髄神経 (CSN) を調べた.
- CSNの活性が低下し,マウスのCSTが切断された.
- 触覚や有害な刺激に対する行動反応と触覚アロディニアの評価
主要な成果:
- 体の感覚神経回路の活動が低下し,CSTの切断により,光への触覚反応が低下した.
- これらの操作は有害な刺激に対する反応に影響を与えなかった.
- CSN操作は触覚アロディニアを弱め 脊髄-皮質-脊髄の感受性ループを明らかにしました
結論:
- 脊髄体感覚処理の直接的な皮質調節が存在する.
- CSTは正常および病的な触覚感覚に役割を果たします.
- ニューロパシー疼痛の新たな治療目標を示唆しています
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