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Updated: Jul 7, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

1つの結合部位は,テトラヒメナ前-rRNAの自己スプライシング,トランススプライシング,RNA酵素活性性のシーケンス特異性を決定する

M D Been, T R Cech

    Cell
    |October 24, 1986
    PubMed
    まとめ

    この研究は,テトラヒメナ前リボソームRNA (rRNA) の干渉配列 (IVS) を調査し,特定の塩基配列規則がRNA酵素活性をどのように支配するかを明らかにします. 配列の変更は,スプライシングの精度と他の触媒機能に影響し,RNA酵素特異性の予測可能な変化を示しています.

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