小さい,明るいリチウムベースのアップコンバーティングナノ粒子
Ting Cheng1, Riccardo Marin1, Artiom Skripka1
1Centre Énergie, Matériaux et Télécommunications , Institut National de la Recherche Scientifique, Université du Québec , Varennes , Quebec J3X 1S2 , Canada.
Journal of the American Chemical Society
|September 15, 2018
まとめ
研究者らは,生物医学的な用途のために,小さな明るいアップコンバーティングナノ粒子 (UCNP) を開発した. これらのナノ粒子は,近赤外線 (NIR) 光を紫外線 (UV) 光に効率的に変換し,光ダイナミック療法のような治療のためのより深い組織浸透を可能にします.
科学分野:
- ナノテクノロジー
- 生物医学工学
- 材料科学
背景:
- 紫外線 (UV) は腫瘍治療に有効ですが,組織への浸透は限られています.
- 近赤外線 (NIR) の光は組織に深く浸透しますが,光化学的プロセスにはエネルギーがありません.
- アップコンバーティングナノ粒子 (UCNP) はNIRをUV光に変換しますが,効率のためにより大きなサイズが必要であり,細胞の吸収を妨げます.
研究 の 目的:
- 小規模で高効率のUCNPを開発し, バイオメディカルアプリケーションに活用する.
- UCNPのサイズとNIRからUVへのアップコンバージョンの効率の間のトレードオフを克服する.
- 深層組織に光を媒介する治療に適したUCNPを作成します.
主な方法:
- リガンド比 (オレアミン/オレイン酸) を制御することによって5nmUCNPを合成した.
- オレイン酸で冷却することでUCNPを安定させ,10nm以下の結晶を生成する.
- NIRからUVへのアップコンバージョンの効率を大幅に高めるため,UCNPコアに殻を育てました.
主要な成果:
- 化学的に安定した,単分散の10nm以下のUCNPを達成した.
- 殻の成長後のNIRからUVへのアップコンバージョンの改善が示されています.
- LiYbF4:Tm3+/LiYF4のUCNPは,より大きなゴールドスタンダードUCNPを上回った.
結論:
- この2段階の戦略により,生物医学的な用途に適した小さな明るいUCNPが得られます.
- これらのUCNPは,深層組織浸透 (NIR) と効率的なUV放出を組み合わせています.
- 開発されたUCNPは,光媒介による腫瘍治療の有意な可能性を示しています.
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