ERストレスは,S1Pのカスパース-2活性化によるリポゲネシスとステアトヘパチスを誘発する

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Updated: Feb 5, 2026

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

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Ju Youn Kim1, Ricard Garcia-Carbonell1, Shinichiro Yamachika1

  • 1Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA.

Cell
|September 18, 2018
PubMed
まとめ

カスパース2の活性化により,非アルコール性脂肪肝疾患 (NAFLD) が非アルコール性脂肪肝炎 (NASH) に進行し,自由コレステロールが増加します. カスパース2を阻害することで,NASHの発症を防ぐことができる.

キーワード:
DNL についてナッシュSREBP についてカスパース-2肝臓ステアトーシス脂質生成肝臓繊維症サイト 1 プロテアゼ

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