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ベンゼン-1,3,5-トリカルボキシアミドのポリモルフィズム水中の超分子組成:構造と動力の微妙なトレードオフ

Nicholas M Matsumoto¹, René P M Lafleur¹, Xianwen Lou¹

¹Institute for Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry , Eindhoven University of Technology , P.O. Box 513, 5600 MB Eindhoven , the Netherlands.

Journal of the American Chemical Society

|September 18, 2018

まとめ

合成の小さな分子であるベンゼン-1,3,5-トリカルボキシアミド (BTA) は水の中でダイナミックなナノチューブを形成する. これらの構造は温度に依存する可逆的な再編成を示し新しい反応性のある材料への道を切り開きます

科学分野:

超分子化学
材料科学
バイオ材料

背景:

ポリモルフィズムとは生物学的現象でバイオマクロモリクルは複数の形をとる.
合成アセンブリにおける制御されたポリモルフィズムがバイオインスピレーションを受けた反応性のある材料の鍵です

研究の目的:

自己組み立て構造を形成できる水溶性ベンゼン-1,3,5-トリカルボキシアミド (BTA) を開発する.
これらのアセンブリ,特にナノチューブの温度依存のダイナミックな再構成を調査する.

主な方法:

炭酸機能化されたBTAの合成
水溶液での自己組み立て試験
構造分析のための小角X線散射 (SAXS) と冷凍伝送電子顕微鏡 (Cryo-TEM).
分子ダイナミクスを測定するための水素-デュテリウム交換.

主要な成果:

BTAは水の中で繊維や膜そして空洞なナノチューブとして自己組織化します
特定のBTA誘導体は温度変化に逆転するナノチューブを形成します
SAXSとCryo-TEMは高温で長方形のナノチューブを確認しました
より高い温度での分子動態の増加は,欠陥のないナノチューブ壁の形成を促進します.

結論:

この研究は,合成BTAを用いた多形性超分子構造の制御された形成を証明した.
温度によるダイナミックな再編成は,明確に定義された,欠陥のないナノチューブアーキテクチャの形成に不可欠です.
これらの発見は,バイオインスピレーションによる高度な反応性のある材料の創造に向けた重要な一歩を表しています.

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