リバーシブル・ヒエラルキカル・アセンブリ・オブ・トライメリック・コイル・コイル・ペプチドス・イン・バンド・ナノ・アンド・マイクロストラクチャー
Monessha Nambiar1, Li-Sheng Wang2, Vincent Rotello2
1Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907-2084 , United States.
Journal of the American Chemical Society
|September 18, 2018
まとめ
研究者たちは 秩序あるナノ構造を形成する 自己組み立てペプチドを開発しました これらのペプチドバイオマテリアルは pHによって制御されていて 薬剤の投与などの応用が期待されています
科学分野:
- 超分子化学
- 材料科学
- バイオ材料工学
背景:
- ペプチドの自己組み立ては 複雑なナノ構造を作るための 重要な戦略です
- ペプチドベースの材料の組み立てと性質を制御することは,高度なアプリケーションにとって極めて重要です.
研究 の 目的:
- 階層的な組み立てのためにバイピリジンで機能したコイルドコイルペプチドの設計と合成.
- これらのペプチドベースのナノおよびマイクロ構造の構造特性と組み立てメカニズムを調査する.
- これらの材料の生物学的応用,特にpH制御薬の投与の可能性を調査する.
主な方法:
- 放射的に機能化されたコイル・コイルペプチドの合成.
- 帯状の長方形構造に階層的な組み立ての特徴.
- 細かい構造的側面と包装を決定するX線散乱分析.
- pH依存の可逆性アセンブリの調査
主要な成果:
- 調節可能なナノおよびマイクロ構造にペプチドの階層的組み立てを示した.
- アロマティックグループ配置と構造の寸法との相関を確立した.
- X線散射によるトリマーの六角包装とインタートリマーの芳香相互作用を特定した.
- 生理学的条件下での容易な形成と,反転可能な pH 調節による集合.
結論:
- バイピリジンで機能したコイルペプチドは,調整可能な次元を持つ階層構造に自己組み立てられます.
- 構造的性質は,芳香基の戦略的配置によって影響を受けます.
- これらのバイオマテリアルは 薬の投与などの 制御された生物学的用途に適した 逆転性pH反応的行動を示します
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