硫化水素を放出する赤光活性化ルテニウムの特徴と生物学的活性 (II) コンプレックス
Joshua J Woods1,2, Jian Cao3, Alexander R Lippert3
1Robert F. Smith School for Chemical and Biomolecular Engineering , Cornell University , Ithaca , New York 14853 , United States.
Journal of the American Chemical Society
|September 20, 2018
まとめ
研究者は,赤色光で活性化されるとのみ硫化水素 (H2S) を放出する新しいルテニウム基剤を開発しました. この制御された放出は心臓細胞を損傷から保護し,H2Sの治療の可能性を研究するための新しいツールを提供します.
科学分野:
- 生物化学
- 化学生物学
- 医学化学
背景:
- 硫化水素 (H2S) は,イシュケミア再注射損傷の治療の可能性を持つ重要なガス伝達物質である.
- 現在のH2S放出前薬は,しばしば水解による無制御の放出に苦しんでおり,その治療的応用が制限されています.
- H2Sの効果的な細胞内投与には,洗練された前薬戦略が必要です.
研究 の 目的:
- 空間時間的な制御を持つ新しいH2S放出剤を開発する.
- 生体細胞における赤色光照射によるH2S放出の活性化を研究する.
- 発光されたH2Sの放出による血栓再注射による損傷に対する保護効果を評価する.
主な方法:
- Ru (II) ベースのH2S放出化合物の合成と特徴付け
- 生きたH9c2心筋芽細胞で赤色光で誘発されたH2S放出を示す.
- 細胞活性の評価と,インビトロにおける不血症再注射損傷モデルに対する保護.
主要な成果:
- 赤色光が活性化すると選択的にH2Sを放出するRu (II) ベースの化合物が合成されました.
- 細胞内H2Sレベルは,赤光照射後にのみ有意に増加した.
- 赤色光で活性化されたH2S放出は,H9c2心筋細胞に,イシュケミア再注血による損傷に対する有意な保護を与えました.
結論:
- 赤色光で活性化されたH2S放出剤は,ガス伝達物質の配送を正確に制御します.
- この技術は,H2Sの生物学的役割と治療用途を調査するための貴重なツールを提供します.
- 開発された薬剤は,イシュケミア-再注射性損傷のような状態で標的治療の可能性を示しています.
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