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Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
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Pyruvate Oxidation01:15

Pyruvate Oxidation

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After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
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Oxidation Numbers03:14

Oxidation Numbers

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In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
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Energy-releasing Steps of Glycolysis01:28

Energy-releasing Steps of Glycolysis

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Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
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Oxidation-Reduction Reactions03:11

Oxidation-Reduction Reactions

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Oxidation–Reduction Reactions
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Oxidation of Alcohols02:37

Oxidation of Alcohols

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In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
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Updated: Feb 5, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
11:28

Analytical Techniques for Assaying Nitric Oxide Bioactivity

Published on: June 18, 2012

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酸化窒素を放出するサイクロデクストリン

Haibao Jin1, Lei Yang1, Mona Jasmine R Ahonen1

  • 1Department of Chemistry , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

Journal of the American Chemical Society
|September 21, 2018
PubMed
まとめ
この要約は機械生成です。

新しいサイクロデクストリン (CD) 誘導体は,Pseudomonas aeruginosaと戦うために窒素酸化物 (NO) を放出する. 適応されたNO放出と外部の改変は,抗菌活性を増強し,二重薬の投与の可能性を示しています.

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Procedures of Laboratory Fumigation for Pest Control with Nitric Oxide Gas
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Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation
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関連する実験動画

Last Updated: Feb 5, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
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Procedures of Laboratory Fumigation for Pest Control with Nitric Oxide Gas
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Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation
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科学分野:

  • バイオマテリアル科学
  • 薬剤化学
  • 薬物の配達

背景:

  • サイクロデクストリン (CD) は,薬剤の投与と治療における潜在能力を有する多用途の宿主です.
  • 窒素酸化物 (NO) は重要な抗菌性を持っていますが,制御された投与システムが必要です.
  • 抗生物質耐性病原体との闘いには,新種のNO放出物質の開発が不可欠です.

研究 の 目的:

  • 新しい二次アミン改変サイクロデクストリン (CD) 誘導体を合成し,特徴づけること.
  • 制御された放出アプリケーションのための窒素酸化物 (NO) ドナーでこれらの誘導体を機能化します.
  • これらのNOを放出するCD誘導体の抗菌効果と潜在的な治療用途を評価する.

主な方法:

  • 多様な末端群を持つ二次アミン改変CD誘導体の合成
  • 塩基条件下で窒素酸化物 (NO) のガス結合により,N-ディアゼニウム二酸化物ドナーが形成される.
  • NOのペイロードの定量化とNO放出運動 (半減期) の決定.
  • Pseudomonas aeruginosaに対する殺菌性の評価
  • 哺乳類のL929マウス繊維細胞に対する細胞毒性の評価.
  • プロメタジンによる二重薬物投与能力の実証

主要な成果:

  • 多様な二次アミン改変CD誘導体を 合成しました
  • 調節可能なNOペイロード (0.6-2.4μmol/mg) と放出半減期 (0.7-4.2h) を達成した.
  • Pseudomonas aeruginosaに対する強力な殺菌作用が示され,NOのペイロードと外部の改変に依存しています.
  • 主要なアミン末端のCDはP. aeruginosaに対して非常に有効である.
  • 主要なアミン末端のヘプタ置換CD誘導体においてのみ,細胞毒性が観察された.
  • プロメタジンなどの二重薬物投与の可能性を示した.

結論:

  • NOを放出する新種のCD誘導体は 微生物を抑制する性質を持っています
  • 高濃度のNOと主要アミンの機能化は,P. aeruginosaに対する殺菌効果を高めます.
  • これらのNOを放出するCDは 細菌感染症の治療薬として有望です
  • 二重薬物投与の応用の可能性は,その治療的有用性を拡大します.