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Updated: Feb 4, 2026
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Recordings of Neural Circuit Activation in Freely Behaving Animals
Published on: July 22, 2009
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腸 が 誘発 する 報酬 の 神経 回路
Wenfei Han1, Luis A Tellez2, Matthew H Perkins3
1The John B. Pierce Laboratory, New Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cell
|September 25, 2018
まとめ
腸-脳軸は 動機と感情に大きな影響を与えます 特定の腸内神経細胞を活性化すると 報酬経路が起動し 気分障害に対する新しい治療法が提案されます
科学分野:
- 神経科学
- 胃腸内科
- 精神科
背景:
- 感情と動機付けの状態を 制御する腸の役割は ますます認識されています
- しかし 腸と脳の報酬系を 繋ぐ神経回路は ほとんど解明されていません
研究 の 目的:
- 報酬の根底にある 腸-脳神経回路を解明するために
- 報酬の経路を媒介する ヴァーガル感覚神経細胞の役割を調査する
主な方法:
- 静脈神経細胞の光学的な活性化
- 自己刺激,味覚,場所の条件付けのための行動分析
- 細胞特異的な神経経路追跡
- ドーパミンの放出量を測定する
主要な成果:
- 右側が動いたが 左側が動かない 持続的な自己刺激行動と 誘発された報酬
- この活性化により,黒い物質のドーパミンが放出され,条件付きの好みが生じます.
- トランスニューロン・トレーシングは,右のヴァーガル・センサリー・ギャングリオンから,ドロスラテラル・パラブラキアル領域を通って,Substantia nigraのドーパミン細胞への特定の経路を特定しました.
- このパラブラキオ・ニグラス・プロジェクションを 活性化させることで 右のヴァガス刺激の効果を模倣しました
結論:
- ヴァーガル・ゲート・トゥ・ブレイン軸は 脳の報酬神経経路の 重要な構成要素です
- これらの発見は,ヴァーガル経路をターゲットにすることで,感情障害に対する新しい治療戦略を提供できると示唆しています.
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