エリトロミエロイドの祖先は,血管に内皮細胞を寄与する
Alice Plein1, Alessandro Fantin1, Laura Denti1
1UCL Institute of Ophthalmology, University College London, London, UK.
Nature
|September 28, 2018
まとめ
胎児の血管は,以前未知の源であるエリトロミエロイド前駆体 (EMP) から新しい内皮細胞を得ます. この発見は 発達中の哺乳類における 血管拡張の二重メカニズムを明らかにしています
科学分野:
- 発達生物学
- ヘマトポエシス
- 血管生物学
背景:
- 胚の血管は血管芽細胞から形成され 内皮細胞へと分化します
- 以前は,内皮細胞の膨張は,単に増殖によって起こると考えられていた.
研究 の 目的:
- 胚の血管発達のための 細胞の代替源を調査する.
- エリトロミエロイド原産体 (EMP) の血管化への貢献を特定する.
主な方法:
- エリトロミエロイド祖先 (EMP) の分化と移動を追跡する.
- EMPが卵黄と胚内血管に与える影響を分析する
主要な成果:
- EMPの第一波は 卵黄の内皮に寄与する
- EMPの第2波が胚を植え込み 胚内内皮を形成し 成人期まで続きます
- EMPは新型の内皮細胞の源です
結論:
- 胚の血管内皮は二重メカニズムで膨張する.
- これは,既存の内皮細胞の増殖と,血液形成前駆体 (EMP) から派生した細胞の組み込みの両方を含む.
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